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p-Nur77 Antibody (Ser 341): sc-16991

 |  Datasheet

(Based on data analysis)

  • p-Nur77 Antibody (Ser 341) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-16991-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Ser 341 of Nur77 of human origin
  • recommended for detection of Ser 341 phosphorylated Nur77 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-16991 P
 

See additional Nur Antibodies.

Ordering InformationGene Info
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-Nur77 Antibody (Ser 341) sc-16991 200 µg/ml $279
p-Nur77 (Ser 341) P sc-16991 P
(peptide)
 100 µg/0.5 ml $61
p-Nur77 Antibody (Ser 341)-R sc-16991-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Nur77 siRNA (h) sc-36109 10 µM $258
Nur77 siRNA (m) sc-36110 10 µM $258
Nur77 siRNA (r) sc-108068 10 µM $258
Nur77 siRNA (h2) sc-156146 10 µM $258
Nur77 (h)-PR sc-36109-PR 10 µM, 20 µl $23
Nur77 (m)-PR sc-36110-PR 10 µM, 20 µl $23
Nur77 (r)-PR sc-108068-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Nur77 shRNA Plasmid (h) sc-36109-SH 20 µg $520
Nur77 shRNA Plasmid (m) sc-36110-SH 20 µg $520
Nur77 shRNA Plasmid (r) sc-108068-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Nur77 shRNA (h) Lentiviral Particles sc-36109-V 200 µl $625
Nur77 shRNA (m) Lentiviral Particles sc-36110-V 200 µl $625
Nur77 shRNA (r) Lentiviral Particles sc-108068-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NR4A1 3164 12q13.13 NM_002135, NM_173157, NM_173158 P22736
 139139
Mouse Nr4a1 15370 15 F2 P12813
 N/A
 

Nur77 (also designated nuclear receptor subfamily 4, group A, member 1, HMR, N10, TR3, NP10, GFRP1, NAK-1, NGFIB) encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of Nur77 from the nucleus to mitochondria induces apoptosis. An increase in Nur77 expression occurs in activated T cells during the G0 to G1 transition and throughout the G1 phase. In addition to its function as an immediate early gene, Nur77 may play a role in TCR-mediated apoptosis. Akt-dependent phosphorylation of Nur77 on Ser 341 and Ser 351 can occur in a phosphatidylinositol 3-kinase-dependent manner, and causes a decrease in Nur77 DNA-binding activity.

p-Nur77 Antibody (Ser 341) Data
Click on image to enlarge
sc-16991
Western blot analysis of Nur77 phosphorylation in non-transfected: sc-110760 (A,D), untreated human Nur77 transfected: sc-112240 (B,E) and lambda protein phosphatase (sc-200312A) treated human Nur77 transfected: sc-112240 (C,F) 293 whole cell lysates. Antibodies tested include p-Nur77 (Ser 341)-R: sc-16991-R (A,B,C) and Nur77 (C-5): sc-365113 (D,E,F).
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