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p-Tau Antibody (Thr 470): sc-16898

 |  Datasheet

(Based on data analysis)
  • p-Tau Antibody (Thr 470) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-16898-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Thr 470 of Tau of human origin
  • recommended for detection of Thr 470 phosphorylated Tau of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-16898 P
 

See additional Tau Antibodies.

Ordering InformationGene Info
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-Tau Antibody (Thr 470) sc-16898 200 µg/ml $279
p-Tau (Thr 470) P sc-16898 P
(peptide)
 100 µg/0.5 ml $61
p-Tau Antibody (Thr 470)-R sc-16898-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Tau siRNA (h) sc-36614 10 µM $258
Tau siRNA (m) sc-36615 10 µM $258
Tau siRNA (h2) sc-43402 10 µM $258
Tau (h)-PR sc-36614-PR 10 µM, 20 µl $23
Tau (m)-PR sc-36615-PR 10 µM, 20 µl $23
Tau (h2)-PR sc-43402-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Tau shRNA Plasmid (h) sc-36614-SH 20 µg $520
Tau shRNA Plasmid (m) sc-36615-SH 20 µg $520
Tau shRNA Plasmid (h2) sc-43402-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Tau shRNA (h) Lentiviral Particles sc-36614-V 200 µl $625
Tau shRNA (m) Lentiviral Particles sc-36615-V 200 µl $625
Tau shRNA (h2) Lentiviral Particles sc-43402-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
mouse brain extract sc-2253 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MAPT 4137 17q21.31 NM_005910, NM_016834, NM_016835, NM_016841 P10636
 601104
Mouse Mapt 17762 11 E1 P10637
 N/A
 

Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, in addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity. Tau is highly subject to a variety of post-translational modifications, including phosphorylation on serine and threonine residues, polyubiquitination (and subsequent proteasomal degradation) and glycation of specific Tau isoforms. Defects in the gene encoding Tau are associated with Alzheimers disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP).