MSL-1 Antibody (Q-19): sc-168661

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MSL-1 (male-specific lethal 1 homolog (Drosophila)), also known as MSL1L1 (male-specific lethal 1-like 1), is a 614 amino acid nuclear protein that forms a multisubunit histone acetyltransferase complex with MOF, MSL-1, MSL-2 and MSL3L1. This complex is responsible for the majority of Histone H4 acetylation at lysine 16. Existing as three alternatively spliced isoforms, MSL-1 is a member of the MSL-1 family and is encoded by a gene that maps to human chromosome 17q21.1. Human chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is liked to predisposition of cancers of the ovary, colon, prostate gland and fallopian tubes.