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p-Ron β Antibody (Tyr 1353): sc-16839

 |  Datasheet

(Based on data analysis)

  • p-Ron β Antibody (Tyr 1353) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-16839-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Tyr 1353 of Ron of human origin
  • recommended for detection of Tyr 1353 phosphorylated Ron of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-16839 P
 

See additional Ron Antibodies including Ron, Ron alpha and Ron beta.

Also see Ron Inhibitors for functional analysis of cellular responses to Ron.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-Ron β (Tyr 1353) P sc-16839 P
(peptide)
 100 µg/0.5 ml $61
p-Ron β Antibody (Tyr 1353)-R sc-16839-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Ron siRNA (h) sc-36434 10 µM $258
Ron siRNA (m) sc-36435 10 µM $258
Ron (h)-PR sc-36434-PR 10 µM, 20 µl $23
Ron (m)-PR sc-36435-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Ron shRNA Plasmid (h) sc-36434-SH 20 µg $520
Ron shRNA Plasmid (m) sc-36435-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Ron shRNA (h) Lentiviral Particles sc-36434-V 200 µl $625
Ron shRNA (m) Lentiviral Particles sc-36435-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MST1R 4486 3p21.31 NM_002447 Q04912
 600168
Mouse Mst1r 19882 9 F1 Q62190
 N/A
 

Ron, also designated STK in mice, is a transmembrane receptor tyrosine kinase that is a member of the Met family and displays 63% homology with Met. The gene encoding human Ron maps to chromosome 3p21 and is expressed as a glycosylated precursor, which is cleaved to produce a heterodimer of alpha and beta disulfide-linked chains. Ron is expressed in several epithelial tissues, granulocytes and monocytes, and it is the membrane bound receptor for macrophage-stimulating protein (MSP), a multifunctional factor that regulates cell adhesion, motility, growth and survival. Binding of MSP to Ron stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a upregulation of Ron catalytic activity and subsequent activation of downstream signaling molecules. In addition, Ron contains putative autophosphorylation sites on Tyr 1353 and Tyr 1360. Ron is thought to play a role in early embryonic development and in the inflammatory response.
p-Ron β Antibody (Tyr 1353) Data
Click on image to enlarge
sc-16839
p-Ron β (Tyr 1353)-R: sc-16839-R. Western blot analysis of Ron β phosphorylation in untreated (A), pervanadate treated (B) and pervanadate and lambda protein phosphatase (sc-200312A) treated (C) A-431 whole cell lysates.
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