p-Calponin 1 (Ser 175)-R Antibody: sc-16717-R

Calponin 1 Background Information
Calponin regulates smooth muscle cell contraction and is a marker of smooth muscle cell differ-entiation. Calponin, an actin- and tropomyosin-binding protein, is characterized as an inhibitory factor of smooth-muscle actomyosin activity. Calponin is implicated in the regulation of smooth muscle contraction through its interaction with F-actin and inhibition of the actin-activated MgATPase activity of phosphorylated myosin. Both properties are lost following phosphorylation (primarily at serine 175) by protein kinase C or calmodulin-dependent protein kinase II. The three forms of Calponin, Calponin 1 (basic calponin), Calponin 2 (neutral calponin), and Calponin 3 (acidic calponin) are found in smooth muscle tissue. Additionally, Calponin 2 is found in heart muscle tissue and Calponin 3 is found in the brain.