Cofilin 2 Antibody (D-5): sc-166958

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Cofilin 2, also known as CFL2 or Cofilin, muscle isoform, is a 166 amino acid protein that localizes to the cytoplasm and the cytoskeleton, as well as to the nuclear matrix, and contains one ADF-H domain. Existing as two alternatively spliced isoforms, one of which is known as CFL2a and is expressed in heart and skeletal muscle, and the other of which is known as CFL2b and is expressed ubiquitously, Cofilin 2 binds both F- and G-Actin and functions to control pH-dependent Actin polymerization and depolymerization. Cofilin 2 is subject to post-translational phosphorylation on Ser 24, an event which may prevent the nuclear localization of Cofilin 2. Defects in the gene encoding Cofilin 2 are the cause of nemaline myopathy type 7 (NEM7), a form of congenital myopathy that varies with age and is characterized by abnormal thread- or rod-like structures in muscle fibers.