NRAMP 2 Antibody (G-5): sc-166884

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Natural resistance associated macrophage proteins (NRAMPs) belong to a super-family of highly conserved integral membrane proteins. NRAMP 1 is an intracellular macrophage protein located at the phagosomal membrane where it functions as a divalent cation transporter for Fe2+, Zn2+ and Mn2+ (1,2). NRAMP 1 is a pH-dependent antiporter that transports metal ions either into or out of the phagosome against a proton gradient (1). The gene encoding human NRAMP 1 maps to chromosome 2q35 (3). In humans, polymorphisms in the NRAMP 1 gene are linked to susceptibility to M. tuberculosis and leprosy (4-6). NRAMP 2 is another divalent cation transporter ubiquitously expressed as two splice variants, which are distinguished by the presence (isoform 1) or absence (isoform 2) of an iron response element (7,8). In the duodenum of the small intestine, dietary iron regulates NRAMP 2 expression at the brush border (9). The gene encoding human NRAMP 2 maps to chromosome 12q13 (8). Mutations in the gene for NRAMP 2 in mice and rats result in severe anemia (10).