COL1A2 Antibody (G-4): sc-166865

COL1A2 Antibody (G-4) is a mouse monoclonal IgM kappa light chain antibody engineered to detect Collagen α2 Type I (COL1A2), also known as Collagen type I alpha 2 chain or simply type I collagen alpha2. Anti-COL1A2 antibody (G-4) targets a precise epitope mapping between amino acids 1070-1087 at the C-terminus of COL1A2, ensuring exceptional specificity and reliability in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Collagen α2 Type I is a vital component of the extracellular matrix, predominantly located in connective tissues like tendons, skin, and bone, where COL1A2 provides structural support and tensile strength essential for tissue integrity. The extracellular localization of COL1A2 is crucial for maintaining the architecture and function of connective tissues, facilitating cell adhesion, and supporting normal physiological processes. Additionally, COL1A2 plays a significant role in the formation and maintenance of complex connective tissues, making COL1A2 a key protein in studies related to connective tissue disorders and fibrosis. COL1A2 monoclonal antibody (G-4) is available in a non-conjugated form, offering flexibility for various experimental designs and enabling researchers to conjugate with different labels as needed. The robust reactivity with human COL1A2 ensures compatibility with human tissue samples, making anti-COL1A2 antibody (G-4) an indispensable tool for both basic research and diagnostic applications.

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COL1A2 Antibody (G-4) References:

1. Collagen and bone strength.  |  Boskey, AL., et al. 1999. J Bone Miner Res. 14: 330-5. PMID: 10027897
2. Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways.  |  Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
3. Cell adhesion to collagenous matrices.  |  McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
4. Nasal tolerance to dominant and subdominant epitopes of collagen type II and protection against collagen-induced arthritis.  |  Staines, NA., et al. 1997. Biochem Soc Trans. 25: 661-4. PMID: 9191176
5. Versatile collagens in invertebrates.  |  Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
6. Collagen-induced arthritis, an animal model of autoimmunity.  |  Myers, LK., et al. 1997. Life Sci. 61: 1861-78. PMID: 9364191
7. The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease.  |  Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL1A2 Antibody (G-4) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-COL1A2 Antibody (G-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL1A2 Antibody (G-4) Specifications

Alternate Product Name: collagen 1 type COL1A2

Product Clone Name: G-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1070-1087

Epitope Target: Collagen α2 Type I

Epitope Species: human

Product Reactivity/Detection: Collagen α2 Type I

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for COL1A2 Antibody (G-4): P: Blocking Peptide

The preferred Pro-COL1A2 antibody is Pro-COL1A2 Antibody (D-6): sc-166572.