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MAG Antibody (A-11): sc-166849

 |  Datasheet

(Based on data analysis)

  • MAG Antibody (A-11) is a mouse monoclonal IgG2a provided at 200 µg/ml
  • raised against amino acids 1-300 mapping near the N-terminus of MAG of human origin
  • recommended for detection of MAG of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
 
Full-length MAG protein sequence with immunogen highlighted:
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK

See additional MAG Antibodies.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
MAG Antibody (A-11) sc-166849 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
MAG siRNA (h) sc-35841 10 µM $258
MAG siRNA (m) sc-35842 10 µM $258
MAG (h)-PR sc-35841-PR 10 µM, 20 µl $23
MAG (m)-PR sc-35842-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
MAG shRNA Plasmid (h) sc-35841-SH 20 µg $520
MAG shRNA Plasmid (m) sc-35842-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
MAG shRNA (h) Lentiviral Particles sc-35841-V 200 µl $625
MAG shRNA (m) Lentiviral Particles sc-35842-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
rat brain extract sc-2392 500 µg/200 µl $104
mouse brain extract sc-2253 500 µg/200 µl $104
MAG (h): 293T Lysate sc-116497 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MAG 4099 19q13.12 P20916
 159460
Mouse Mag 17136 7 B1 P20917
 N/A
 

Myelin-associated glycoprotein (MAG) is a nervous system cell-surface adhesion protein that is involved in linking myelinating glial cells to neuronal axons. MAG contains a sialic acid binding site and five IgG-like domains, thus identifying MAG as a member of a subgroup of the immunoglobulin superfamily. Like myelin, MAG inhibits axonal outgrowth and contributes to the inhibitory properties of myelin. Growth inhibition by MAG has been shown to be blocked when cerebellar neurons are pre-incubated with the neurotrophins BDNF or GDNF. It is suggested that this neurotrophin priming elevates cAMP and activates PKA.
MAG Antibody (A-11) Data
Click on image to enlarge
sc-166849
MAG (A-11): sc-166849. Western blot analysis of MAG expression in non-transfected: sc-117752 (A) and human MAG transfected: sc-116497 (B) 293T whole cell lysates.
sc-166849
MAG (A-11): sc-166849. Western blot analysis of MAG expression in mouse brain tissue extract.
sc-166849
MAG (A-11): sc-166849. Immunoperoxidase staining of formalin fixed, paraffin-embedded human brain tissue showing neuropil staining.
sc-166849
MAG (A-11): sc-166849. Western blot analysis of MAG expression in human hippocampus (A) and rat brain (B) tissue extracts.
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