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Tra-2β Antibody (D-2): sc-166829

 |  Datasheet

(Based on data analysis)

  • Tra-2β Antibody (D-2) is a mouse monoclonal IgG2a provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 10-50 near the N-terminus of Tra-2β of human origin
  • recommended for detection of Tra-2β of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-166829 X, 200 µg/0.1 ml
 

See additional Tra-2 Antibodies including Tra-2 alpha, Tra-2 beta and Tra-2.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Tra-2β Antibody (D-2) sc-166829 200 µg/ml $279
Tra-2β Antibody (D-2) X sc-166829 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Tra-2β siRNA (h) sc-38566 10 µM $258
Tra-2β siRNA (m) sc-38567 10 µM $258
Tra-2β (h)-PR sc-38566-PR 10 µM, 20 µl $23
Tra-2β (m)-PR sc-38567-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Tra-2β shRNA Plasmid (h) sc-38566-SH 20 µg $520
Tra-2β shRNA Plasmid (m) sc-38567-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Tra-2β shRNA (h) Lentiviral Particles sc-38566-V 200 µl $625
Tra-2β shRNA (m) Lentiviral Particles sc-38567-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HeLa nuclear extract sc-2120 250 µg/0.05 ml $143
IMR-32 nuclear extract sc-2148 250 µg/0.05 ml $143
SK-N-MC nuclear extract sc-2154 250 µg/0.05 ml $143
K-562 nuclear extract sc-2130 250 µg/0.05 ml $143
HL-60 nuclear extract sc-2147 250 µg/0.05 ml $143
Tra-2 (h2): 293T Lysate sc-176571 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SFRS10 6434 3q27.2 P62995
 602719
Mouse Sfrs10 20462 16 B1 P62996
 N/A
 

Human transformer-2 alpha (Tra-2å) and Tra-2∫ are nuclear proteins that associate with distinct pre-mRNA splicing enhancer elements. Tra-2å is the functional homolog of the Drosophila TRA-2 protein, which regulates the female specific pre-mRNA splicing pattern of the doublesex (dsx) gene in Drosophila. Human Tra-2 proteins are able to actively splice Drosophila sex factors; however, human Tra-2å has not been shown to induce sexual differentiation suggesting that human Tra-2å may regulate splicing patterns involving alternative mechanisms. Tra-2å and Tra-2∫ contain a single RNP-type RNA-binding domain and selectively bind to purine-rich sequences to facilitate mRNA splicing. Expression of Tra-2∫ is upregulated during the reoxygenation of hypoxic astrocytes. Tra-2å and Tra-2∫ interact with the serine/arginine-rich (SR) family of splicing factors to form Tra-2/SR complexes that then regulate tissue-specific alternative splicing patterns of many pre-mRNAs.

Tra-2β Antibody (D-2) Data
Click on image to enlarge
sc-166829
Tra-2β (D-2): sc-166829. Western blot analysis of Tra-2β expression in HeLa (A) and IMR-32 (B) nuclear extracts.
sc-166829
Tra-2β (D-2): sc-166829. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing nuclear staining of glandular cells.
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