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PC-1 Antibody (F-8): sc-166649

 |  Datasheet

(Based on data analysis)

  • PC-1 Antibody (F-8) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against amino acids 11-120 mapping near the N-terminus of PC-1 of human origin
  • recommended for detection of PC-1 of human origin by WB, IP, IF, IHC(P) and ELISA
 
Full-length PC-1 protein sequence with immunogen highlighted:
MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED

See additional PC-1 Antibodies.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
PC-1 Antibody (F-8) sc-166649 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PC-1 siRNA (h) sc-40811 10 µM $258
PC-1 siRNA (m) sc-40812 10 µM $258
PC-1 (h)-PR sc-40811-PR 10 µM, 20 µl $23
PC-1 (m)-PR sc-40812-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PC-1 shRNA Plasmid (h) sc-40811-SH 20 µg $520
PC-1 shRNA Plasmid (m) sc-40812-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PC-1 shRNA (h) Lentiviral Particles sc-40811-V 200 µl $625
PC-1 shRNA (m) Lentiviral Particles sc-40812-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
MIA PaCa-2 Cell Lysate sc-2285 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ENPP1 5167 6q23.2 P22413
 602475
Mouse Enpp1 18605 10 A4 P06802
 N/A
 

PC-1, also known as ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) or membrane component, chromosome 6, surface marker-1 (M6S1), is the human homolog of Ly-41 in the mouse. PC-1 is a homodimer with restricted tissue distribution, being first characterized in plasma cells. In addition to its expression on plasma cells, PC-1 is expressed on hepatocytes, renal tubules, salivary duct epithelium, epididymis, capillary endothelium in the brain and chondrocytes. Most patients with non-insulin-dependent diabetes mellitus (NIDDM) are resistant to both endogenous and exogenous insulin. Insulin resistance precedes the onset of this disease, suggesting that it may be an initial abnormality. It has been suggested that PC-1 may have a role in the insulin resistance of NIDDM by direct interaction with the receptor a subunit. The gene which encodes PC-1 maps to human chromosome 6q22-q23, which is a common site for deletions in human lymphoid neoplasia.
PC-1 Antibody (F-8) Data
Click on image to enlarge
sc-166649
PC-1 (F-8): sc-166649. Western blot analysis of PC-1 expression in MIA PaCa-2 whole cell lysate.
sc-166649
PC-1 (F-8): sc-166649. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing membrane staining of glandular cells.
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