Rabex-5 Antibody (D-11): sc-166496

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Rabex-5 (Rab 5 GDP/GTP exchange factor), also known as RABGEF1, RAP1 or RABAPTIN-5-associated exchange factor for Rab 5, is a Rab guanine nucleotide exchange factor. Rabex-5 localizes to the cytoplasm and can associate with early endosomes. It consists of an N-terminal zinc finger domain, a GEF domain, an EET (early endosomal targeting) domain and a coiled-coil domain. The EET domain is important for the association of Rabex-5 with early endosomes and for the activation of Rab 5. Truncated Rabex-5 that is missing its EET domain can still function via an association with RABAPTIN-5. The Rabex-5/RABAPTIN-5 complex can target to early endosomes in a Rab 5-dependent manner through the binding of Rab5-GTP to RABAPTIN-5. In vitro, Rabex-5 exhibits GEF activity on its own, however, its association with RABAPTIN-5 increases its efficiency.