MPP4 Antibody (B-2): sc-166396

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Progression of cells from interphase to mitosis involves alterations in cell structures and activities. The transition from G2 to M phase is induced by M phase-promoting factor (MPF). In M phase, many proteins are phosphorylated directly by MPF or indirectly by kinases activated by MPF. These M phase phosphoproteins (MPPs), also known as MPHOSPHs, permit disassembly of interphase structures and generation of M phase enzymatic activities and structures. MPP4, also known as membrane protein, palmitoylated 4, MAGUK p55 subfamily member 4, ALS2CR5, discs large homolog 6 (DLG6), or amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein, is a 637 amino acid protein and member of the MAGUK family that localizes to cytoplasm and likely plays a role in the development of retinal photoreceptors. MPP4 is highly expressed in retina, and weakly expressed in testis and brain. MPP4 contains one guanylate kinase-like domain, one SH3 domain, one PDZ (DHR) domain and two L27 domains. Due to alternative splicing events, five MPP4 isoforms exist. Studies suggest MPP4 may be responsible for autosomal recessive retinitis pigmentosa 26 (RP26), as the two genes co-localize on human chromosome 2q33.1.