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- mouse monoclonal IgG2b, 200µg/ml
- specific for an epitope mapping between amino acids 645-672 at the C-terminus of ACSL3 of human origin
- recommended for detection of ACSL3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
ACSL3 |
2181 |
2q36.1 |
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O95573
|
602371 |
| Mouse |
Acsl3 |
74205 |
1 C4 |
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Q9CZW4
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N/A |
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ACSL3 Background Information
Acyl-CoA synthetases, also known as long-chain fatty-acid CoA synthases (ACSL) or Palmitoyl-CoA ligases, include ACSL1-6, which are all single-pass membrane proteins localizing to the mitochondrion, microsome or peroxisome. ACSL proteins are important for synthesis of cellular lipids and for ∫-oxidation degradation. Specifically, ACSL proteins catalyze the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO2, triacylglycerol (TAG), phospholipids (PL) and cholesteryl esters (CE). ACSL3 preferentially utilizes laurate, myristate, arachidonate and eicosapentaenoate among saturated and unsaturated long chain fatty acids. ACSL3 is expressed as two isoforms in various tissues, including brain, heart, placenta, prostate, skeletal muscle, testis and thymus. ACSL4 preferentially utilizes arachidonate and is abundant in steroidogenic tissues. ACSL4 may modulate female fertility and uterine prostaglandin production. |
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ACSL3 (H-9)
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ACSL3 (H-9): sc-166374. Western blot analysis of ACSL3 expression in TE671 whole cell lysate.
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