G_{β (A-4) Antibody: sc-166250}

G_{β Background Information}
Heterotrimeric G proteins transduce extracellular signals received by transmembrane receptors to effector proteins (1). Each subunit of the G protein complex is encoded by a member of 1 of 3 corresponding gene families (å, ∫, ©) and in mammals there are 5 different members of the ∫-subunit family (1). The ∫ subunits of the G proteins are important regulators of G protein a subunits as well as of certain signal transduction receptors and effectors (2). The gene which encodes transducin ∫1 maps to human chromosome 1pter-p31.2 (3,4). The gene which encodes transducin ∫2 maps to human chromsome 7q21 (4,5). The gene which encodes transducin ∫3 maps to human chromosome 12p13 (6). In contrast to ∫1-4, which are at least 83% homologous, transducin ∫5 is only 50% homologous to the other ∫ subunits (7). Human transducin ∫5 is expressed at high levels in brain, pancreas, kidney, and heart (7). The gene which encodes transducin ∫5 maps to human chromsome 15 (2).