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PNK Antibody (B-4): sc-166188

 |  Datasheet

(Based on data analysis)

  • PNK Antibody (B-4) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against amino acids 222-521 mapping at the C-terminus of PNK of human origin
  • recommended for detection of PNK of human origin by WB, IP, IF and ELISA
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-166188 X, 200 µg/0.1 ml
 
Full-length PNK protein sequence with immunogen highlighted:
MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEETRTPESQPDTPPGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAEEFKAKVEAVVEKLGVPFQVLVATHAGLYRKPVTGMWDHLQEQANDGTPISIGDSIFVGDAAGRPANWAPGRKKKDFSCADRLFALNLGLPFATPEEFFLKWPAAGFELPAFDPRTVSRSGPLCLPESRALLSASPEVVVAVGFPGAGKSTFLKKHLVSAGYVHVNRDTLGSWQRCVTTCETALKQGKRVAIDNTNPDAASRARYVQCARAAGVPCRCFLFTATLEQARHNNRFREMTDSSHIPVSDMVMYGYRKQFEAPTLAEGFSAILEIPFRLWVEPRLGRLYCQFSEG

See additional PNK Antibodies.

Also see PNK Inhibitors for functional analysis of cellular responses to PNK.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
PNK Antibody (B-4) sc-166188 200 µg/ml $279
PNK Antibody (B-4) X sc-166188 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PNK siRNA (h) sc-44826 10 µM $258
PNK siRNA (m) sc-45370 10 µM $258
PNK siRNA (h)-PR sc-44826-PR 10 µM, 20 µl $23
PNK siRNA (m)-PR sc-45370-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PNK shRNA Plasmid (h) sc-44826-SH 20 µg $520
PNK shRNA Plasmid (m) sc-45370-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PNK siRNA shRNA (h) Lentiviral Particles sc-44826-V 200 µl $625
PNK siRNA shRNA (m) Lentiviral Particles sc-45370-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HeLa nuclear extract sc-2120 250 µg/0.05 ml $143
Jurkat nuclear extract sc-2132 250 µg/0.05 ml $143
PC-3 nuclear extract sc-2152 250 µg/0.05 ml $143
rat testis extract sc-2400 500 µg/200 µl $104
PNK (h): 293T Lysate sc-115119 100 µg/200 µl $205
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PNKP 11284 19q13.33 Q96T60
 605610
Mouse Pnkp 59047 7 B4 Q9JLV6
 N/A
 

Bifunctional polynucleotide phosphatase/kinase (PNK), also referred to as polynucleotide kinase-3'-phosphatase, is a member of the DNA 3’ phosphatase family. PNK is the protein expressed by the gene PNKP and contains a 3'-phosphatase domain with similarity to L-2-haloacid dehalogenases and a reported ATP binding site. PNK is a nuclear protein that is involved in DNA repair following damage caused by radiation or oxidation. The protein catalyzes the phosphorylation of DNA at the hydroxy termini but can also dephosphorylate its 3’-phosphate termini. The highest levels of expression of PNK occur in testis, pancreas, spleen, kidney and heart.

PNK Antibody (B-4) Data
Click on image to enlarge
sc-166188
PNK (B-4): sc-166188. Western blot analysis of PNK expression in non-transfected: sc-117752 (A) and human PNK transfected: sc-115119 (B) 293T whole cell lysates.
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