CENPJ Antibody (E-12): sc-166113

---

CENPJ (CPAP) is a centromeric protein that plays a role in brain size. The protein contains five coiled-coil domains, the most C-terminal of which includes a leucine zipper motif. CENPJ also has several potential protein phosphoryl-ation sites and a C-terminal domain containing 21 nonamer G-box repeats. The CENPJ gene is expressed in neuroepithelium during prenatal neurogenesis, and it localizes to the spindle poles of cells undergoing mitosis. This localization suggests that a centrosomal mechanism controls neuron number in the developing mammalian brain. Mutations in the CENPJ gene have been linked to the condition autosomal recessive primary microcephaly. A novel 4 bp deletion in the gene has been characterized as a cause of protein truncation leading to the condition.