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p-Vav2 Antibody (Tyr 172)-R: sc-16409-R

 |  Datasheet

(Based on data analysis)
  • p-Vav2 (Tyr 172)-R Antibody is a rabbit polyclonal IgG provided at 200 µg/ml
  • recommended for detection of Tyr 172 phosphorylated Vav2 of mouse, rat and human origin by WB and IF; also reactive with additional species, including equine, canine, porcine and avian
  • blocking peptide, sc-16409 P
 

See additional Vav Antibodies including Vav, Vav2 and Vav3.

Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-Vav2 (Tyr 172) P sc-16409 P
(peptide)
 100 µg/0.5 ml $61
p-Vav2 (Tyr 172)-R Antibody sc-16409-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Vav2 siRNA (h) sc-41738 10 µM $258
Vav2 siRNA (m) sc-41739 10 µM $258
Vav2 (h)-PR sc-41738-PR 10 µM, 20 µl $23
Vav2 (m)-PR sc-41739-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Vav2 shRNA Plasmid (h) sc-41738-SH 20 µg $520
Vav2 shRNA Plasmid (m) sc-41739-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Vav2 shRNA (h) Lentiviral Particles sc-41738-V 200 µl $625
Vav2 shRNA (m) Lentiviral Particles sc-41739-V 200 µl $625

Vav proteins are guanine nucleotide exchange factors for Rho family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Vav proteins contain several protein binding domains which can link cell surface receptors to downstream signaling proteins. Vav3 is a Ros receptor protein tyrosine kinase (RPTK) interacting protein and has a broad tissue expression profile that is distinct from those of Vav and Vav2. Vav3 mediates RPTK signaling and regulates GTPase activity, its native and mutant forms are able to modulate cell morphology, and it has the potential to induce cell transformation. For example, Vav3 induces marked membrane ruffles and microspikes in NIH/3T3 cells. Vav works as a GDP/GTP exchange factor for Rac GTPases, thereby facilitating the transition of these proteins from the inactive (GDP-bound) into the active (GTP-bound) state. The stimulation of Vav exchange activity during cell signaling is mediated by tyrosine phosphorylation. The residue, Tyrosine 174, is phospho-rylated following the stimulation of mitogenic and antigenic receptors. This phosphorylation event is conserved in Vav2 and Vav3, the other two members of the Vav family.