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home » Membrane Receptors » FR Antibody / FR Antibodies » FR (C-17): sc-16388

FR (C-17) Antibody: sc-16388

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping near the C-terminus of FR of human origin
  • recommended for detection of α-, β- and γ-FR of human origin, and to a lesser extent, β-FR of mouse and rat origin origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-16388 P
 
Additional FR Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human FOLR1 2348 11q13.4 NM_000802, NM_016724, NM_016725, NM_016729, NM_016730, NM_016731 P15328
 136430
Human FOLR2 2350 11q13.4 NM_000803 P14207
 136425
Human FOLR3 2352 11q13.4 NM_000804 P41439
 602469
Mouse Folr1 14275 7 E3 P35846
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
FR (C-17) sc-16388 200 µg/ml $279
FR (C-17) P sc-16388 P
(peptide)
 100 µg/0.5 ml $61
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
JAR Cell Lysate sc-2276 500 µg/200 µl $104

FR Background Information
Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydofolate into the cell. The folate receptors consist of five members, å, ∫, ©, ©’ (which is produced by alternative splicing) and ∂. å-FR and ∫-FR are attached to the membrane by a GPI anchor and are expressed in malignant tissues of epithelial and nonepithelial origin, respectively. ©-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow, but the expression pattern of ∂-FR is elusive, which suggests that it is highly restricted both spatially and temporally. å-FR is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.

FR (C-17) Product Citations
See how others have used FR (C-17): sc-16388 antibody and or FR (C-17) antibody conjugates.


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