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p-GM130 Antibody (Ser 25): sc-16306

 |  Datasheet

(Based on data analysis)
  • p-GM130 Antibody (Ser 25) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-16306-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Ser 25 of GM130 of human origin
  • recommended for detection of Ser 25 phosphorylated GM130 by mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
  • blocking peptide, sc-16306 P
  • See 2 citations for p-GM130 Antibody (Ser 25)
 

See additional GM130 Antibodies.

Ordering InformationProduct CitationsGene Info
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-GM130 Antibody (Ser 25) sc-16306 200 µg/ml $279
p-GM130 (Ser 25) P sc-16306 P
(peptide)
 100 µg/0.5 ml $61
p-GM130 Antibody (Ser 25)-R sc-16306-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
GM130 siRNA (h) sc-41224 10 µM $258
GM130 siRNA (m) sc-41225 10 µM $258
GM130 (h)-PR sc-41224-PR 10 µM, 20 µl $23
GM130 (m)-PR sc-41225-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
GM130 shRNA Plasmid (h) sc-41224-SH 20 µg $520
GM130 shRNA Plasmid (m) sc-41225-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
GM130 shRNA (h) Lentiviral Particles sc-41224-V 200 µl $625
GM130 shRNA (m) Lentiviral Particles sc-41225-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GOLGA2 2801 9q34.11 NM_004486 Q08379
 602580
Mouse Golga2 99412 2 B Q921M4
 N/A
 

The docking of transport vesicles to their target membrane is mediated by p115. GM130, a cis-Golgi matrix protein, interacts specifically with p115 and provides a membrane docking site. Both GM130 and p115 are involved in vesicle tethering to Golgi membranes. The amino-terminus of GM130 binds to p115, whereas the carboxy-terminus binds to Golgi membranes. Both giantin and GM130 compete for binding to p115. Thus, p115-giantin and p115-GM130 interactions might mediate independent membrane tethering events. Transport from the ER to the cis/medial Golgi compartments requires the action of p115, GM130 and giantin via a sequential rather than a coordinate mechanism. Mitotic phosphorylation of GM130 at Serine 25 is mediated by Cdc2, prevents binding to p115, and is directly involved in mitotic Golgi fragmentation. GM130 is phosphorylated in prophase as the Golgi complex starts to break down, and remains phosphorylated in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble.

p-GM130 Antibody (Ser 25) Product Citations
See how others have used p-GM130 Antibody (Ser 25) and or p-GM130 Antibody (Ser 25) conjugates.


2 total citations
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