SH3D19 Antibody (G-13): sc-162191

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SH3D19 (SH3 domain-containing protein 19), also known as EBP, EEN-binding protein, EVE1 or Kryn, is a 790 amino acid protein that is widely expressed with highest expression in kidney, heart, lung, liver, skeletal muscle and small intestine. Localized to the cytoplasm and recruited to the nucleus by a fusion protein known as MLL-EEN (mixed-lineage leukemia-endophilin), SH3D19 is thought to play a role in regulating the involvement of ADAM (A disintegrin and metalloproteases) proteins in EGFR (epidermal growth factor receptor)-ligand shedding pathways. SH3D19 contains five SH3 domains and may also function to suppress both Ras-induced cellular transformation and Ras-associated activation of proteins such as Elk-1. Translocation events involving the SH3D19 gene are implicated in acute myeloid leukemia, suggesting a possible role for SH3D19 in carcinogenesis. Five isoforms of SH3D19 are expres-sed due to alternative splicing events.