RAB3IP Antibody (S-14): sc-162069

---

The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies all of which are thought to play an important role in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum (ER) to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. RAB3IP (RAB3A interacting protein), also known as Rabin-3 or SSX2-IP, is a 406 amino acid protein that localizes to both the nucleus and the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed in placenta, brain, heart, pancreas and kidney, RAB3IP interacts with Rab 3A, Rab 3B and SSX2 and, via this interaction, may regulate Rab function, as well as SSX2-induced malignancies.