epitope mapping within an internal region of Neuron navigator 1 of human origin
recommended for detection of Neuron navigator 1 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with Neuron navigator 2 or Neuron navigator 3
Neuron navigator 1 Background Information Neuron navigator 1, also known as Unc-53 homolog 1, Steerin-1 and POMFIL3 (Pore membrane and/or filament-interacting-like protein 3), is a 1877 amino acid cytoplasmic protein that is involved in neuronal migration. Neuron navigtor 1 is widely expressed at low levels, though highest expression is found in both adult and fetal nervous tissue. Through interaction with tubulin, Neuron navigator 1 associates with a subset of mirotubule plus ends present in the growth cone. Overexpression of Neuron navigator 1 leads to microtubule bundling, whereas a reduction of its levels causes loss of directionality in the migration of pontine cell leading processes. There are seven isoforms of Neuron navigator 1 that are produced as a result of alternative splicing events.
Neuron navigator 1 (T-13)
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Neuron navigator 1 (T-13): sc-161935. Western blot analysis of Neuron navigator 1 expression in T24 whole cell lysate.
Neuron navigator 1 (T-13): sc-161935. Western blot analysis of Neuron navigator 1 expression in SK-N-MC (A), JAR (B) and OV-90 (C) whole cell lysates.
