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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of KV1.4 of human origin
- recommended for detection of KV1.4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-16179 P
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
KCNA4 |
3739 |
11p14.1 |
NM_002233 |
P22459
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176266 |
| Mouse |
Kcna4 |
16492 |
2 E3 |
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Q61423
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N/A |
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KV1.4 Background Information
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming å-subunits (KVå), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV∫ subunits that modify the gating properties of the coexpressed KVå subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels. |
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KV1.4 (F-20)
Click on image to enlarge
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KV1.4 (F-20): sc-16179. Western blot analysis of KV1.4 expression in SK-N-SH (A) and U-87 MG (B) whole cell lysates.
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