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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of RHAMM of human origin
- recommended for detection of RHAMM isoforms A and B of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-16170 P
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RHAMM Background Information
Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration (1). HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM) (1,2). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility (2,3). RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction (2–4). Although still unclear, RHAMM is thought to exist as several isoforms ranging in size (3,5,6). A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts (3).
| RHAMM (E-19) Product Citations |
See how others have used RHAMM (E-19): sc-16170 antibody and or RHAMM (E-19) antibody conjugates.
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RHAMM (E-19)
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RHAMM (E-19): sc-16170. Western blot analysis of RHAMM expression in mouse brain tissue extract.
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