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- goat polyclonal IgG, 200µg/ml
- epitope mapping within an internal region of P4HA2 of human origin
- recommended for detection of P4HA2 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with P4HA1 or P4HA3 ; also reactive with additional species, including canine, bovine and porcine
- blocking peptide, sc-161146 P
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
P4HA2 |
8974 |
5q31.1 |
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O15460
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600608 |
| Mouse |
P4ha2 |
18452 |
11 B1.3 |
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Q60716
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N/A |
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P4HA2 Background Information
P4HA1 (prolyl 4-hydroxylase, alpha polypeptide I) and P4HA2 (prolyl 4-hydroxylase, alpha polypeptide II) are 534 and 535 amino acid proteins, respectively, that each localize to the lumen of the endoplasmic reticulum and contain one TPR repeat, as well as one PKHD domain. Using ascorbate and iron as cofactors, P4HA1 and P4HA2 catalyze the post-translational formation of 4-hydroxyproline in collagens and other proteins, thereby playing an essential role in the proper folding of newly synthesized peptides. P4HA1 exists as a heterotetramer of two alpha-1 and two beta chains, while P4HA2 exists as a heterotetramer of two alpha-2 chains and two beta chains. Both P4HA1 and P4HA2 exists as multiple alternatively spliced isoforms. |
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P4HA2 (S-15)
Click on image to enlarge
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P4HA2 (S-15): sc-161146. Western blot analysis of P4HA2 expression in non-transfected 293T: sc-117752 (A), human P4HA2 transfected 293T: sc-115446 (B) and A-10 (C) whole cell lysates. |
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