SELENBP1 Antibody (K-12): sc-160788

---

Selenium is an essential trace element that is incorporated as selenocysteine into the primary structure of selenoproteins. Nutritional deficiency of selenium decreases selenoprotein concentrations and leads to pathologic conditions. Most of the known selenoproteins are members of the glutathione peroxidase or iodothyronine deiodinase families. SELENBP1 (selenium binding protein 1), also known as LPSB or SP56, is a 472 amino acid peripheral membrane protein that binds selenium and is implicated in detecting xenobiotics in cytoplasm. Existing as two alternatively spliced isoforms and a member of the selenium-binding protein family, SELENBP1 is likely involved in intra-Golgi protein transport, selenium-dependent cell growth inhibition and ubiquitination/deubiquitination-mediated protein degradation. SELENBP1 is highly expressed in prostate, lung, kidney, pancreas and liver, and is upregulated in the blood and brain of schizophrenia patients.