Na⁺ CP type IIα (S-15) Antibody: sc-16033

Na⁺ CP type IIa Background Information
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming å subunit, a noncovalently associated ∫1 subunit and a disulfide-linked ∫2 subunit. The two ∫ subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The å subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIå subunits are more abundant along axons. The ∫1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, ∫1 and ∫2 are highly expressed in Purkinje cells, and ∫1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.