epitope mapping within an internal region of HERG of human origin
recommended for detection of HERG of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine and canine
HERG Background Information Human ether-a-go-go related gene (HERG) encodes the pore-forming å subunit of the delayed rectifier potassium channel IKr. The HERG subunit contains six transmembrane å-helices with a reentrant “pore-loop” between the fifth and the sixth transmembrane helices. The two N-terminal splice variants of HERG include the full-length isoform 1å and the shorter isoform 1∫. Isoform 1∫ lacks the PAS motif and deactivates at a faster rate than isoform 1å. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome.
HERG (N-20) Product Citations
See how others have used HERG (N-20): sc-15966 antibody and or HERG (N-20) antibody conjugates.
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HERG (N-20)
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HERG (N-20): sc-15966. Western blot analysis of HERG expression in EOC 20 (A) and EOC 13.31 (B) whole cell lysates and rat (C) and mouse (D) heart tissue extracts.
