epitope mapping within an internal region of EBF of human origin
recommended for detection of EBF1 and EBF3 of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including equine, canine, bovine, porcine and avian
EBF Background Information B lymphocyte maturation is an intricate process that requires a distinct set of transcription factors with respect to the stage of cell differentiation and cell lineage. Among the transcriptional regulators involved in the early stages of B cell development, early B cell factor (EBF), also designated olfactory neuronal transcription factor 1 (OLF1), targets promoter elements for B lymphoid kinase (Blk) and genes encoding portions of the early stage B cell receptors (BCR), which are necessary for initiation of Ig light chain gene recombination and Src kinase (Blk) signaling. EBF is a basic helix-loop-helix (bHLH) homodimeric transcription factor composed of two subunits that interact with the core DNA sequence, CCCNNGGG, through a DNA recognition domain containing a zinc-coordination motif. Promoter elements to certain neuron-specific genes encoding olfactory-related proteins have been shown to contain EBF binding sites.
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EBF (C-20)
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EBF (C-20): sc-15888. Western blot analysis of EBF expression in human PBL whole cell lysate.
EBF (C-20): sc-15888. Western blot analysis of EBF expression in Ramos (A) and 3611-RF (B) nuclear extracts.
