epitope mapping near the C-terminus of NUMB of human origin
recommended for detection of NUMB of mouse, rat and human origin by WB, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
NUMB Background Information Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR). Mammalian NUMB homologs play a role in the determination of cell fates during development and bind with EPS15, LNX1, and NOTCH1. Conditional mouse mutants with deletion of NUMB in developing sensory ganglia show a reduction in axonal arborization in afferent fibers. Changes in cellular calcium homeostasis influences NUMB-dependent cell fate decisions during development of the nervous system. Chicken NUMB (c-NUMB) protein is localized to the basal cortex of mitotic neuroepithelial cells.
NUMB (P-20) Product Citations
See how others have used NUMB (P-20): sc-15590 antibody and or NUMB (P-20) antibody conjugates.
5 total citations
Loading citations.
NUMB (P-20)
Click on image to enlarge
NUMB (P-20): sc-15590. Immunoperoxidase staining of formalin fixed, paraffin-embedded human ovary tissue showing membrane localization.
