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home » Neurobiology » NUMB Antibody / NUMB Antibodies » NUMB (N-20): sc-15588

NUMB (N-20) Antibody: sc-15588

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping within an internal region of NUMB of human origin
  • recommended for detection of NUMB of mouse, rat and human origin by WB, IF and ELISA
  • blocking peptide, sc-15588 P
 
Additional NUMB Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NUMB 8650 14q24.2 NM_001005743, NM_001005744, NM_001005745, NM_003744 P49757
 603728
Mouse Numb 18222 12 D1 Q9QZS3
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
NUMB (N-20) sc-15588 200 µg/ml $279
NUMB (N-20) P sc-15588 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NUMB siRNA (h) sc-42146 10 µM $258
NUMB siRNA (m) sc-42147 10 µM $258
NUMB (h)-PR sc-42146-PR 10 µM $23
NUMB (m)-PR sc-42147-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NUMB shRNA Plasmid (h) sc-42146-SH 20 µg $520
NUMB shRNA Plasmid (m) sc-42147-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NUMB shRNA (h) Lentiviral Particles sc-42146-V 200 µl $625
NUMB shRNA (m) Lentiviral Particles sc-42147-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
T98G Cell Lysate sc-2294 500 µg/200 µl $104

NUMB Background Information
Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR). Mammalian NUMB homologs play a role in the determination of cell fates during development and bind with EPS15, LNX1, and NOTCH1. Conditional mouse mutants with deletion of NUMB in developing sensory ganglia show a reduction in axonal arborization in afferent fibers. Changes in cellular calcium homeostasis influences NUMB-dependent cell fate decisions during development of the nervous system. Chicken NUMB (c-NUMB) protein is localized to the basal cortex of mitotic neuroepithelial cells.

NUMB (N-20) Product Citations
See how others have used NUMB (N-20): sc-15588 antibody and or NUMB (N-20) antibody conjugates.


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