IRS-2 Antibody (M-19): sc-1555

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IRS-2, originally described as 4PS, acts as a signaling intermediate downstream of the insulin, IGF-1, IL-4, IL-9 and IL-13 receptors (1). In IRS-2-deficient mice, reduction in total PI 3-kinase activity by 30% and abolition of downstream activation of protein kinase C (PKC) zeta leads to the development of type 2 diabetes (3). Additionally, reconstitution with retroviral IRS-2 restores IRS-2/PI 3-kinase/PKC zeta signalling as well as glucose uptake (3). IRS-2 translocates to the nuclei of mouse embryo fibroblasts expressing the insulin-like growth factor 1 receptor (4). Various mutations in the IGF-IR can result in an abrogation of or decrease in the translocation of IRS proteins to the nucleoli (4). IRS-2 is responsible for mitogen-activated protein kinase (MAPK) and protein kinase B (PKB) activation by insulin and is the major adapter molecule linking the insulin receptor to this step (5).