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home » Lymphocyte Signaling » BLNK Antibody / BLNK Antibodies » BLNK (H-80): sc-15345

BLNK (H-80) Antibody: sc-15345

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 201-280 mapping to an internal region of BLNK of human origin
  • recommended for detection of BLNK p70 and BLNK p68 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine and porcine
 
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Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human BLNK 29760 10q23.33 NM_013314 Q8WV28
 604515
Mouse Blnk 17060 19 C3 Q9QUN3
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
BLNK (H-80) sc-15345 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
BLNK siRNA (h) sc-29810 10 µM $258
BLNK siRNA (m) sc-29811 10 µM $258
BLNK (h)-PR sc-29810-PR 10 µM $23
BLNK (m)-PR sc-29811-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
BLNK shRNA Plasmid (h) sc-29810-SH 20 µg $520
BLNK shRNA Plasmid (m) sc-29811-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
BLNK shRNA (h) Lentiviral Particles sc-29810-V 200 µl $625
BLNK shRNA (m) Lentiviral Particles sc-29811-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
BJAB Whole Cell Lysate sc-2207 500 µg/200 µl $104
Ramos Cell Lysate sc-2216 500 µg/200 µl $104
NAMALWA Cell Lysate sc-2234 500 µg/200 µl $104

BLNK Background Information
Cross-linking of the B cell receptor (BCR) activates a variety of signaling pathways involved in processes such as cell proliferation and apoptosis. Intracellular protein tyrosine kinases such as Syk and Lyn have been implicated in this BCR signal transduction and are thought to play an important role in B cell development. BLNK (for B cell linker protein) is a central linker protein in B cells which has been shown to associate with the effector proteins GRB2, Vav, Nck and PLC © following activation of the B cell receptor. The two forms of BLNK, pp68 and pp70, arise from alternate splicing of the human BLNK gene transcript. BLNK is phosphorylated by the Syk tyrosine kinase, which in turn permits activation of downstream effector proteins including GRB2 and PLC ©.

BLNK (H-80) Product Citations
See how others have used BLNK (H-80): sc-15345 antibody and or BLNK (H-80) antibody conjugates.


3 total citations
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BLNK (H-80)
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sc-15345
BLNK (H-80): sc-15345. Western blot analysis of BLNK expression in BJAB (A), Ramos (B) and HuT 78 (C) whole cell lysates.
sc-15345
BLNK (H-80): sc-15345. Immunoperoxidase staining of formalin fixed, paraffin-embedded human appendix tissue showing cytoplasmic staining of glandular cells and lymphoid tissue (low and high magni?fication). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
sc-15345
BLNK (H-80): sc-15345. Western blot analysis of BLNK expression in Ramos whole cell lysate.
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