epitope corresponding to amino acids 921-1120 mapping near the C-terminus of NCAM-L1 of human origin
recommended for detection of NCAM-L1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and bovine
NCAM-L1 Background Information Cell adhesion molecules are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to play an important role in embryogenesis and development. Neuronal cell adhesion molecule (NCAM) expression is observed in a variety of human tumors, including neuroblastomas, rhabdomyosarcomas, Wilm’s tumors, Ewing’s sarcomas and some primitive myeloid malignancies. The NCAM-L1 adhesion molecule (CD171) plays an important role in axon guidance and cell migration in the nervous system. The presence of NCAM-L1 might contribute to tumor progression by promoting cell adhesion and migration and is known to be expressed by neurons, neuroblastomas and other malignant tumors.
NCAM-L1 (H-200) Product Citations
See how others have used NCAM-L1 (H-200): sc-15326 antibody and or NCAM-L1 (H-200) antibody conjugates.