epitope corresponding to amino acids 1-300 of MAG of human origin
recommended for detection of MAG of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
MAG Background Information Myelin-associated glycoprotein (MAG) is a nervous system cell-surface adhesion protein that is involved in linking myelinating glial cells to neuronal axons. MAG contains a sialic acid binding site and five IgG-like domains, thus identifying MAG as a member of a subgroup of the immunoglobulin superfamily. Like myelin, MAG inhibits axonal outgrowth and contributes to the inhibitory properties of myelin. Growth inhibition by MAG has been shown to be blocked when cerebellar neurons are pre-incubated with the neurotrophins BDNF or GDNF. It is suggested that this neurotrophin priming elevates cAMP and activates PKA.
MAG (H-300) Product Citations
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MAG (H-300)
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MAG (H-300): sc-15324. Western blot analysis of MAG expression in mouse brain tissue extract.
MAG (H-300): sc-15324. Immunoperoxidase staining of formalin fixed, paraffin-embedded human malignant glioma tissue showing membrane staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
MAG (H-300): sc-15324. Immunoperoxidase staining of formalin fixed, paraffin-embedded human brain tissue showing positive staining in neuropil.
