epitope corresponding to amino acids 391-603 mapping at the C-terminus of dopamine beta hydroxylase of human origin
recommended for detection of dopamine beta hydroxylase (DBH) of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine and bovine
DBH Background Information Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline in the biosynthesis of catecholamines. DBH is selectively expressed in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, and it serves as a specific protein marker for noradrenergic processes. The active form of DBH is a homotetramer, which is found in the lumen of synaptic vesicles of corresponding nerve cells, where it localizes to both the membrane and cytosol. DBH is induced by nerve growth factor and insulin growth factor-1 and is regulated by intracellular second messengers protein kinase A, cyclic AMP, diacyl glycerol and Ca2+. Expression of DBH is transcriptionally mediated by Sp1, CREB and AP-1 proteins including c-Fos, c-Jun and JunD.
DBH (H-213) Product Citations
See how others have used DBH (H-213): sc-15318 antibody and or DBH (H-213) antibody conjugates.
4 total citations
Loading citations.
DBH (H-213)
Click on image to enlarge
DBH (H-213): sc-15318. Western blot analysis of DBH expression in non-transfected: sc-117752 (A) and human DBH transfected: sc-159870 (B) 293T whole cell lysates.
DBH (H-213): sc-15318. Western blot analysis of human recombinant DBH fusion protein.
