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EAAT2 Antibody (H-85): sc-15317

 |  Datasheet

(Based on data analysis)

  • EAAT2 Antibody (H-85) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 1-85 mapping at the N-terminus of EAAT2 (excitatory amino acid transporter 2) of human origin
  • recommended for detection of EAAT2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including porcine
  • See 5 citations for EAAT2 Antibody (H-85)
 
Full-length EAAT2 protein sequence with immunogen highlighted:
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDIMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKREK

See additional EAAT Antibodies including EAAT, EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5.

Also see chemical EAAT2 Inhibitors for functional analysis of cellular responses to EAAT2.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
EAAT2 Antibody (H-85) sc-15317 200 µg/ml $279
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EAAT2 CRISPR/Cas9 KO Plasmid (m) sc-422984 20 µg $345
EAAT2 HDR Plasmid (m) sc-422984-HDR 20 µg $385
EAAT2 CRISPR/Cas9 KO Plasmid (h) sc-416579 20 µg $345
EAAT2 HDR Plasmid (h) sc-416579-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EAAT2 siRNA (h) sc-35255 10 µM $258
EAAT2 siRNA (m) sc-35256 10 µM $258
EAAT2 siRNA (r) sc-270106 10 µM $258
EAAT2 (h)-PR sc-35255-PR 10 µM, 20 µl $23
EAAT2 (m)-PR sc-35256-PR 10 µM, 20 µl $23
EAAT2 (r)-PR sc-270106-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EAAT2 shRNA Plasmid (h) sc-35255-SH 20 µg $520
EAAT2 shRNA Plasmid (m) sc-35256-SH 20 µg $520
EAAT2 shRNA Plasmid (r) sc-270106-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EAAT2 shRNA (h) Lentiviral Particles sc-35255-V 200 µl $625
EAAT2 shRNA (m) Lentiviral Particles sc-35256-V 200 µl $625
EAAT2 shRNA (r) Lentiviral Particles sc-270106-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
rat brain extract sc-2392 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SLC1A2 6506 11p13 NM_004171 P43004
600300
Mouse Slc1a2 20511 2 E2 P43006
N/A
 


Excitatory amino acid transporter 1 (EAAT1) is one of the two glial glutamate transporters that clear the extracellular glutamate generated during neuronal signal transmission. Excitatory amino acid transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The reuptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. Three glutamate transporters have been identified in human brain, designated EAAT1-3. EAAT1 and EAAT3 are also expressed in various non-nervous tissues, while EAAT2 expression appears to be restricted to the brain. Surface expression of the glial glutamate transporter EAAT1 is stimulated by insulin-like growth factor 1 through activation of phosphatidylinositol-3-kinase.

EAAT2 Antibody (H-85) Product Citations
See how others have used EAAT2 Antibody (H-85) and or EAAT2 Antibody (H-85) conjugates.


5 total citations
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EAAT2 Antibody (H-85) Data
Click on image to enlarge
EAAT2 (H-85): sc-15317. Western blot analysis of EAAT2 expression in mouse brain (A) and rat brain (B) tissue extracts.
EAAT2 (H-85): sc-15317. Immunoperoxidase staining of formalin fixed, paraffin-embedded human brain tissue showing cytoplasmic staining of neuronal cells.
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