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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of Ral A of human origin
- recommended for detection of Ral A of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-1530 P
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
RALA |
5898 |
7p14.1 |
NM_005402 |
P11233
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179550 |
| Mouse |
Rala |
56044 |
13 A2 |
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P63321
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N/A |
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Ral A Background Information
Ral A and Ral B constitute a distinct subfamily of Ras-related GTPases (i.e., GDP/GTP binding proteins) (1-3). Ral proteins are activated by a unique nucleotide exchange factor, Ral GDS, and deactivated by a distinct GTPase-activating protein (4,5). Unlike Ras proteins, Ral A and Ral B fail to induce transformed foci when activated variants are expressed in various recipient cells (1). A potential downstream target of Ral, designated Ral BP-1, has been shown to contain a Rho-GTPase-activating domain (1). This Rho-GTPase-activating domain interacts preferentially with the Rho family member Cdc42 (1). A Ras/Ral signaling pathway has been reported to mediate phospholipase D (PLD) activation by v-Src, thus indicating PLD as another downstream target of Ral A (6). |
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Ral A (C-19)
Click on image to enlarge
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Ral A (C-19): sc-1530. Western blot analysis of Ral A expression in non-transfected: sc-117752 (A) and human Ral A transfected: sc-115540 (B) 293T whole cell lysates. |
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