TIF1α (C-18) Antibody: sc-15258

TIF1α Background Information
TIF1a mediates transcriptional events by interactions with the AF2 region of several nuclear receptors, such as the estrogen, retinoic acid and vitamin D3 receptors. TIF1a localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. TIF1a is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains (RING, B-box type 1 and B-box type 2) and a coiled-coil region. The TIF1a gene, which maps to human chromosome 7q34, encodes two alternatively spliced transcripts. However, the full length nature of one variant has not been determined. A TIF1a homolog (designated bonus) has been identified in Drosophila and is associated with several genes that are implicated in the ecdysone pathway, a nuclear hormone receptor pathway required throughout Drosophila development, suggesting a conserved functional role for the protein throughout the course of evolution.