epitope mapping near the N-terminus of PRDM4 of rat origin
recommended for detection of PRDM4 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
PRDM4 Background Information The positive regulatory (PR) domain defines a family of zinc-finger transcription factors involved in cell differentiation and tumorigenesis (1-5). One member of the PR domain family is PRDM4, a protein that is differentially controlled by neurotrophin and serum conditions (2). PRDM4 is characterized by an internal PR domain and six carboxy-terminal zinc finger motifs (1,3). PRDM4 interacts with the p75 neurotrophin receptor and is redistributed from the cytoplasm to the nucleus following NGF treatment of transfected cells, suggesting that PRDM4 may provide a downstream transducer for the effects of NGF through the p75 neurotrophin receptor (2). Under normal growth conditions, PRDM4 is predominantly found in the cytoplasm; however, upon serum-starvation, PRDM4 also translocates into the nucleus (2). The gene encoding human PRDM4 maps to chromosome 12q23-q24.1, a region involved in harboring tumor suppressor genes, suggesting a role for PRDM4 in events associated with growth arrest (1-3).
