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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of Cdk8 of human origin
- recommended for detection of Cdk8 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-1521 P
- agarose conjugate for IP studies, sc-1521 AC, 500 µg/0.25 ml agarose
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
CDK8 |
1024 |
13q12.13 |
NM_001260 |
P49336
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603184 |
| Mouse |
Cdk8 |
264064 |
5 G3 |
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Q8R3L8
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N/A |
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Cdk8 Background Information
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Large complexes containing Cdk8, cyclin C and the large subunit of RNA polymerase II have been identified. Cdk8 is thought to regulate RNA polymerase II function in conjunction with cyclin C. Cdk8 has been demonstrated to function as a transcriptional activator when fused to the DNA binding domain of GAL4.
| Cdk8 (C-19) Product Citations |
See how others have used Cdk8 (C-19): sc-1521 antibody and or Cdk8 (C-19) antibody conjugates.
25 total citations Loading citations.
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Cdk8 (C-19)
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Cdk8 (C-19): sc-1521. Western blot analysis of Cdk8 expression in K-562 (A), Jurkat (B), HeLa (C), NIH/3T3 (D) and KNRK (E) nuclear extracts.
Cdk8 (C-19): sc-1521. Immunofluorescence staining of methanol-fixed Jurkat cells showing nuclear localization.
Cdk8 siRNA (h): sc-29267. Immunofluorescence staining of methanol-fixed, control HeLa (A) and Cdk8 siRNA silenced HeLa (B) cells showing diminished nuclear staining in the siRNA silenced cells. Cells probed with Cdk8 (C-19): sc-1521. Cdk8 (C-19): sc-1521. Western blot analysis of Cdk8 expression in K-562 nuclear extract.
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