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home » Signaling Intermediates » Mdr Antibody / Mdr Antibodies » Mdr (C-19): sc-1517

Mdr (C-19) Antibody: sc-1517

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-1517-R
  • epitope mapping at the C-terminus of Mdr -1 of human origin
  • recommended for detection of Mdr-1, Mdr-2 and Mdr-3 of mouse and rat origin and Mdr-1 and Mdr-3 of human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-1517 P
  • fluorescein (sc-1517 FITC) and rhodamine (sc-1517 TRITC) conjugates for immunofluorescence, 200 µg/ml
  • Alexa Fluor® 405 (sc-1517 AF405), Alexa Fluor® 488 (sc-1517 AF488) and Alexa Fluor® 647 (sc-1517 AF647) conjugates for immunofluorescence; 100 µg/2 ml
 
Additional Mdr Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ABCB1 5243 7q21.12 NM_000927 P08183
 171050
Mouse Abcb1b 18669 5 A1 P06795
 N/A
Mouse Abcb4 18670 5 A1 P21440
 N/A
Mouse Abcb1a 18671 5 A1 P21447
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Mdr (C-19) sc-1517 200 µg/ml $279
Mdr (C-19) Alexa Fluor® 405 sc-1517 AF405 100 µg/2 ml $314
Mdr (C-19) Alexa Fluor® 488 sc-1517 AF488 100 µg/2 ml $314
Mdr (C-19) Alexa Fluor® 647 sc-1517 AF647 100 µg/2 ml $314
Mdr (C-19) FITC sc-1517 FITC 200 µg/ml $282
Mdr (C-19) P sc-1517 P
(peptide)
 100 µg/0.5 ml $61
Mdr (C-19)-R sc-1517-R 200 µg/ml $279
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MES-SA/Dx5 Cell Lysate sc-2284 500 µg/200 µl $104
ZR-75-1 Cell Lysate sc-2241 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

Mdr Background Information
Cells selected for resistance to a single cytotoxic drug may become cross-resistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (Mdr). The Mdr proteins are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance observed in human cancer cells following prolonged chemotherapy. The classic form of Mdr is associated with an increase in the Mdr protein, but not all cases of Mdr can be attributed to a rise in Mdr levels. In cell lines not expressing increased levels of Mdr, there is also an increase in the level of a protein designated Mdr-associated protein (MRP).

Mdr (C-19) Product Citations
See how others have used Mdr (C-19): sc-1517 antibody and or Mdr (C-19) antibody conjugates.


12 total citations
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Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
 
Mdr (C-19)
Click on image to enlarge
sc-1517
Mdr (C-19): sc-1517. Western blot analysis of Mdr (P-glycoprotein) expression in MES-SA/Dx5 whole cell lysate.
sc-1517
Mdr (C-19): sc-1517. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing membrane and cytoplasmic staining.
sc-1517
Mdr (C-19) Alexa Fluor 488: sc-1517 AF488. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.
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