epitope mapping within an internal region of Hex of human origin
recommended for detection of Hex of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
blocking peptide, sc-15128 P
TransCruz reagent for Gel Supershift and ChIP applications sc-15128 X, 200 µg/0.1 ml
Hex Background Information The homeobox protein Hex, also known as proline-rich homeodomain protein (Prh), is encoded by a divergent homeobox gene that is transiently expressed in many hematopoietic lineages, suggesting involvement in cellular differentiation. Hex plays a critical role in inducing differentiation of vascular endothelial cells, in the development and maintenance of several organs derived from foregut endoderm, such as the lung, liver and thyroid gland, and in thyroid cell differentiation. Specifically, Hex is expressed in the developmental phases of the thyroid, lung, liver, thymus, gallbladder and pancreas, and in the adult thyroid, lung and liver. Hex also mediates transcriptional induction of the SMemb/NMHC-B gene via its homeodomain and can function as a transcriptional modulator of CRE-dependent transcription in vascular smooth muscle cells (VSMCs). Hex, a soluble protein, is detected in both the nucleus and cytoplasm of transfected and nontransfected cultured cells.
