TRPC3/6/7 Antibody (N-18): sc-15056

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Transient receptor potential cation (TRPC) channels are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPC subtypes mediate store-operated Ca2+ entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. TRPC ion channels influence calcium-depletion induced calcium influx processes in response to chemo-, mechano- and osmoregulatory events. Human TRPC3 protein, also known as TRP3, is a cation channel that is predominantly expressed in brain. The activation of store-mediated Ca2+ entry in human cells likely occurs through the association between IP3R (inositol 1,4,5-trisphosphate receptors) and TRPC3. TRPC3 activity is also activated by DAG (diacylglycerol) independently of PKC (protein kinase C). Human TRPC6 is predominantly expressed in placenta, spleen, lung, small intestine and ovary. Also activated by diacylglycerol (DAG), TRPC6 comprises the a1-adrenoceptor-activated Ca(2+)-permeable cation channel.