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home » Cell Cycle Proteins » DHFR Antibody / DHFR Antibodies » DHFR (C-20): sc-14780

DHFR (C-20) Antibody: sc-14780

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping near the C-terminus of DHFR of human origin
  • recommended for detection of DHFR and DHFRL1 of human origin and DHFR of mouse and rat origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-14780 P
 
Additional DHFR Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human DHFR 1719 5q14.1 NM_000791 P00374
 126060
Human DHFRL1 200895 3q11.2 NM_176815 Q86XF0
 n/a
Mouse Dhfr 13361 13 C3 P00375
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
DHFR (C-20) sc-14780 200 µg/ml $279
DHFR (C-20) P sc-14780 P
(peptide)
 100 µg/0.5 ml $61
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
Y79 Cell Lysate sc-2240 500 µg/200 µl $104
KNRK Whole Cell Lysate sc-2214 500 µg/200 µl $104

DHFR Background Information
Dihydrofolate reductase (DHFR) catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and is a crucial enzyme for the synthesis of purines, pyrimidines and some amino acids. Inhibition of the activity of this enzyme leads to arrest of DNA synthesis and cell death. Gene expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.

DHFR (C-20) Product Citations
See how others have used DHFR (C-20): sc-14780 antibody and or DHFR (C-20) antibody conjugates.


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DHFR (C-20)
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sc-14780
DHFR (C-20): sc-14780. Western blot analysis of DHFR expression in Hela whole cell lysate.
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