epitope mapping near the N-terminus of NRAGE of human origin
recommended for detection of NRAGE of human and rat origin and Dixin-1 of mouse origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and porcine
NRAGE Background Information The neurotrophin family of growth factors (NGF) function to regulate neuronal differentiation, synaptic activity and neuronal survival, as well as axonal and dendritic growth. The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. Neurotrophin receptor-interacting MAGE homolog (NRAGE) binds the p75 neurotrophin re-ceptor and associates with the plasma membrane when NGF binds p75NTR. The critical factors for NRAGE association lie within the juxtamembrane domain of p75NTR. Overexpression of NRAGE stimulates cell cycle arrest and allows NGF-dependent apoptosis within sympathetic neuron precursors cells. NRAGE is expressed in the medulla oblongata during development and motor-neurons. Structural similarities suggest NRAGE, and the MAGE protein necdin, (Ndn), mediate cell cycle effects through a shared mechanism.
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NRAGE (T-20)
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NRAGE (T-20): sc-14398. Western blot analysis of NRAGE expression in non-transfected: sc-117752 (A) and human NRAGE transfected: sc-114826 (B) 293T whole cell lysates.
NRAGE (T-20): sc-14398. Western blot analysis of NRAGE expression in non-transfected: sc-117752 (A) and mouse NRAGE transfected: sc-122121 (B) 293T whole cell lysates.
