OPN1SW (N-20) Antibody: sc-14363

OPN1SW Background Information
G protein-coupled receptors (GPCRs), which are characterized by containing seven transmembrane å helices, elicit G protein-mediated signaling cascades in response to a variety of stimuli. The opsin subfamily, which represents approximately 90 percent of all GPCRs, is comprised of photoreceptors that are activated by light. It includes the red, green and blue-sensitive opsins and rhodopsin. The opsin subfamily consists of an apoprotein covalently linked to 11-cis-retinal, which undergoes isomerization upon the absorption of photons. This isomerization leads to a conformational change of the protein, which results in the activation of hundreds of G proteins. Color is perceived in humans by three pigments, which localize to retinal cone photoreceptor cells. They are the blue-, green- and red-sensitive opsins, which are encoded by OPN1SW, OPN1MW and OPN1LW, respectively. Mutations in the OPN1MW and OPN1LW encoded opsins lead to the X-linked disorders protanopia and deuteranopia, respectively. Mutations in the OPN1SW encoded opsin leads to tritanopia, an autosomal dominant disorder, which is characterized by decreased sensitivity to blue light.