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home » Neurobiology » X11 Antibody / X11 Antibodies » X11α (H-265): sc-14032

X11α (H-265) Antibody: sc-14032

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 1-265 mapping at the N-terminus of X11α of human origin
  • recommended for detection of X11α of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine and canine
 
Additional X11 Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human APBA1 320 9q21.11 NM_001163 Q02410
 602414
Mouse Apba1 319924 19 B NP_796008
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
X11α (H-265) sc-14032 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
X11α siRNA (h) sc-36851 10 µM $258
X11α siRNA (m) sc-36852 10 µM $258
X11α (h)-PR sc-36851-PR 10 µM $23
X11α (m)-PR sc-36852-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
X11α shRNA Plasmid (h) sc-36851-SH 20 µg $520
X11α shRNA Plasmid (m) sc-36852-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
X11α shRNA (h) Lentiviral Particles sc-36851-V 200 µl $625
X11α shRNA (m) Lentiviral Particles sc-36852-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
mouse brain extract sc-2253 500 µg/200 µl $104
rat brain extract sc-2392 500 µg/200 µl $104

X11α Background Information
The ∫-Amyloid precursor protein (∫-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The ∫-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular ∫-APP and slowing ∫-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of ∫-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11∫ (Mint 2) and X11© (Mint 3).

X11α (H-265) Product Citations
See how others have used X11α (H-265): sc-14032 antibody and or X11α (H-265) antibody conjugates.


3 total citations
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X11α (H-265)
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sc-14032
X11α (H-265): sc-14032. Western blot analysis of X11α expression in mouse brain tissue extract.
sc-14032
X11α (H-265): sc-14032. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebral cortex tissue showing cytoplasmic and nuclear staining of neuronal and glial cells (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
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