epitope corresponding to amino acids 661-770 mapping at the C-terminus of Disabled 2 (Dab2) of human origin
recommended for detection of Dab2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
Dab2 Background Information Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl (1). Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants (2). Reelin is a secreted protein thought to play a role in directing migrating neurons (3). Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain (4). Dab2 (also designated DOC-2) is a mitogen-responsive phosphoprotein that binds the SH3 domain of GRB2, and it is thought to be a negative regulator of growth (5).
Dab2 (H-110) Product Citations
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Dab2 (H-110)
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Dab2 (H-110): sc-13982. Western blot analysis of Dab2 expression in H4 whole cell lysate.
Dab2 (H-110): sc-13982. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of trophoblastic cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Dab2 (H-110): sc-13982. Western blot analysis of Dab2 expression in non-transfected 293T: sc-117752 (A), mouse Dab2 transfected 293T: sc-119651 (B) and Y79 (C) whole cell lysates.
Dab2 (H-110): sc-13982. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing apical plasma membrane and cytoplasmic staining of cells in tubules.
